Gary Taubes : Calories vs Carbohydrates

Gary Taubes Calories vs Carbohydrates: Clearing up Confusion over Competing Obesity Paradigms

The science of obesity has been dogged for a century by a controversial question: is the condition an energy balance problem or a hormonal one? Do we accumulate excess fat merely because we consume more calories than we expend — we eat too much and exercise too little — or do we accumulate excess fat because the homeostatic mechanisms regulating fat metabolism and storage are out of whack. If the latter is the case, then positive energy balance (overeating) is an effect of getting fat, not a cause, and the prime environmental suspect for the cause of excess adiposity is the carbohydrate content of the diet and its effect on insulin signaling. This video by author Gary Taubes covers how we might tell these two scenarios apart and potential experiments to resolve this century-old conflict.

Examining metabolic therapy for brain cancer

Metabolic oncology is a relatively new area of cancer research and has the potential to offer new insights into cancer cells’ molecular flexibility, new biomarkers and even targeted therapies. “Metabolism” in this context refers to the metabolic activity inside cancer cells, not the rate at which the body processes energy from food.
Cancer cells are hungry. To feed their rapid growth and division, their metabolism changes. Moreover, they use sugar (glucose) in a different way to normal cells.

The animation below, created by Nature Reviews Drug Discovery, explores the key aspects of the altered metabolism in cancer cells and explains how these can be exploited for the development of new anticancer strategies.

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