Study: almost half of Alzheimer’s cases are due to hyperinsulinemia – Medical News Today

Melissa Schilling, an innovation professor at NYU, has discovered the pathway between diabetes and Alzheimer’s, and it has big implications for how Alzheimer’s can be prevented.

Professor Schilling compared and integrated decades of research on diabetes, Alzheimer’s, and molecular chemistry, focusing in particular on results that seemed to yield conflicting results. It turns out that routine practices in research – like excluding all patients with known medical problems such as diabetes from an Alzheimer’s study, for example – had obscured the mechanisms that connect the two diseases. Those main mechanisms turn out to be insulin and the enzymes that break it down. The same enzymes that break down insulin also break down amyloid-beta, the protein that forms tangles and plaques in the brains of people with Alzheimer’s. When people have hyperinsulinemia (i.e., they secrete too much insulin due to a poor diet, pre-diabetes, early diabetes, obesity, etc.) the enzymes are too busy breaking down insulin to break down amyloid-beta, causing amyloid-beta to accumulate

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Sugar and Cancer

The list of problems caused by sugar in all its forms just goes on and on.  If you hadn’t previously thought of sugar as a cancer trigger, think again.

The reader’s digest version:  when we eat sugar, or white flour, or foods with a high ‘glycemic index’, the blood levels of glucose rise rapidly.  The body immediately releases a dose of insulin to enable the glucose to enter the cells.  The secretion of insulin is accompanied by the release of another molecule, called IGF (insulin-Like growth factor), whose role it is to stimulate cell growth.

And therein lies the root of the cancer-sugar problem.

Insulin and IGF not only stimulate the growth of cancer cells but also their capacity to invde neighboring tissues.  In addition, insulin and IGF promote inflammation, which also stimulates cell growth and acts in turn as fertilizer for tumors.

From Anticancer: A New Way of Life, by David Servan-Schreiber MD, PhD

When David Servan-Schreiber, a dedicated scientist and doctor, was diagnosed with brain cancer, his life changed. Confronting what medicine knows about the illness and the little-known workings of his body’s natural cancer ­fighting capacities.

 

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